Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | PRKCI | P41743 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.34 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30084195 | 1.00 | AXL (0.43) | AXLPRKCIALDH1A1METJAK2 | |
| SCHEMBL24678745 | 0.81 | AXL (0.43) | AXLPRKCIJAK2JAK1TYK2 | |
| SCHEMBL30084296 | 0.81 | AXL (0.43) | AXLPRKCIJAK2JAK1TYK2 | |
| SCHEMBL24679180 | 0.79 | AXL (0.39) | AXLPRKCIALDH1A1METJAK2 | |
| SCHEMBL24678866 | 0.79 | AXL (0.39) | AXLPRKCIALDH1A1JAK2JAK1 | |
| SCHEMBL30084260 | 0.79 | AXL (0.39) | AXLPRKCIALDH1A1METJAK2 | |
| SCHEMBL30084257 | 0.79 | AXL (0.39) | AXLPRKCIALDH1A1JAK2JAK1 | |
| SCHEMBL30084254 | 0.79 | AXL (0.39) | AXLPRKCIALDH1A1METJAK2 | |
| SCHEMBL1935167 | 0.79 | PRKCI (0.54) | AXLPRKCIALDH1A1JAK2JAK1 | |
| SCHEMBL29486783 | 0.79 | PRKCI (0.54) | AXLPRKCIALDH1A1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022247676-A1 | COMPOUND WITH DIPYRROLOPYRIDINE STRUCTURE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 南京康屹生物医药中心(有限合伙) | 2022-12-01 | — | — | WO | disclosed |
| CN-115385911-A | Compound with dipyrrolopyridine structure, preparation method and medical application | 南京康屹生物医药中心(有限合伙) | 2022-11-25 | — | — | CN | disclosed |
| CN-113292561-A | Compound with dipyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |