Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 13/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 6/20 | 0.39 |
| ▸ | JAK1 | P23458 | 6/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30105765 | 0.79 | JAK1 (0.54) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL24678767 | 0.79 | JAK1 (0.54) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL28921687 | 0.79 | JAK2 (0.53) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL28613682 | 0.79 | JAK2 (0.53) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL30084315 | 0.76 | JAK2 (0.58) | PRKCIJAK2JAK3JAK1TYK2 | |
| SCHEMBL24678168 | 0.76 | JAK2 (0.58) | PRKCIJAK2JAK3JAK1TYK2 | |
| SCHEMBL24678443 | 0.76 | JAK2 (0.58) | PRKCIJAK2JAK3JAK1TYK2 | |
| SCHEMBL30084313 | 0.76 | JAK2 (0.58) | PRKCIJAK2JAK3JAK1TYK2 | |
| SCHEMBL28898689 | 0.76 | JAK2 (0.58) | PRKCIJAK2JAK3JAK1TYK2 | |
| SCHEMBL30084204 | 0.76 | JAK2 (0.58) | PRKCIJAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022247676-A1 | COMPOUND WITH DIPYRROLOPYRIDINE STRUCTURE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 南京康屹生物医药中心(有限合伙) | 2022-12-01 | — | — | WO | disclosed |