Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914546 | 1.00 | MAPK1 (0.54) | MAPK1PIK3CAPIK3CDPIK3CBAOC3 | |
| SCHEMBL24681516 | 1.00 | MAPK1 (0.54) | MAPK1PIK3CAPIK3CDPIK3CBAOC3 | |
| SCHEMBL24681215 | 0.90 | MAPK1 (0.57) | MAPK1MAPKAPK2MAPK9PARP10PARP11 | |
| SCHEMBL29914550 | 0.90 | MAPK1 (0.57) | MAPK1MAPKAPK2MAPK9PARP10PARP11 | |
| SCHEMBL24681606 | 0.90 | MAPK1 (0.57) | MAPK1MAPKAPK2MAPK9PARP10PARP11 | |
| SCHEMBL24681217 | 0.81 | MAPK1 (0.56) | MAPK1MAPKAPK2MAPK9 | |
| SCHEMBL29914421 | 0.81 | MAPK1 (0.56) | MAPK1MAPKAPK2MAPK9 | |
| SCHEMBL24681096 | 0.81 | MAPK1 (0.56) | MAPK1MAPKAPK2MAPK9 | |
| SCHEMBL24681093 | 0.81 | MAPK1 (0.56) | MAPK1MAPKAPK2MAPK9 | |
| SCHEMBL29914588 | 0.81 | MAPK1 (0.56) | MAPK1MAPKAPK2MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |