Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 7/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914385 | 1.00 | MAPK1 (0.47) | MAPK1FYNTGFBR1ACVR1ATR | |
| SCHEMBL29914600 | 0.88 | MAPK1 (0.52) | MAPK1FYNTGFBR1ACVR1RIPK2 | |
| SCHEMBL24680722 | 0.88 | MAPK1 (0.52) | MAPK1FYNTGFBR1ACVR1RIPK2 | |
| SCHEMBL24681143 | 0.88 | MAPK1 (0.42) | MAPK1PIK3CA | |
| SCHEMBL29914518 | 0.88 | MAPK1 (0.42) | MAPK1PIK3CA | |
| SCHEMBL29964242 | 0.87 | MAPK1 (0.54) | MAPK1 | |
| SCHEMBL24680920 | 0.86 | MAPK1 (0.47) | MAPK1FYNTGFBR1ACVR1RIPK2 | |
| SCHEMBL29914464 | 0.86 | MAPK1 (0.47) | MAPK1FYNTGFBR1ACVR1RIPK2 | |
| SCHEMBL31079257 | 0.85 | SMARCA2 (0.40) | MAPK1TGFBR1ACVR1ATRALK | |
| SCHEMBL29964997 | 0.85 | RET (0.40) | MAPK1TGFBR1ACVR1ATRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |