Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 4/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914414 | 1.00 | MAPK1 (0.50) | MAPK1FYNMAPKAPK2PARP10PARP11 | |
| SCHEMBL24681258 | 0.88 | MAPK1 (0.54) | MAPK1FYNMAPKAPK2PARP10PARP11 | |
| SCHEMBL29914452 | 0.88 | MAPK1 (0.54) | MAPK1FYNMAPKAPK2PARP10PARP11 | |
| SCHEMBL24680719 | 0.88 | MAPK1 (0.54) | MAPK1FYNMAPKAPK2PARP10PARP11 | |
| SCHEMBL24680726 | 0.88 | MAPK1 (0.54) | MAPK1FYNMAPKAPK2PARP10PARP11 | |
| SCHEMBL29914454 | 0.88 | MAPK1 (0.54) | MAPK1FYNMAPKAPK2PARP10PARP11 | |
| SCHEMBL27157639 | 0.87 | CHEK1 (0.45) | MAPK1MAPKAPK2PARP10PARP11TGFBR1 | |
| SCHEMBL27157660 | 0.87 | CHEK1 (0.45) | MAPK1MAPKAPK2PARP10PARP11TGFBR1 | |
| SCHEMBL24680896 | 0.86 | FYN (0.61) | MAPK1FYNMAPKAPK2TGFBR1ACVR1 | |
| SCHEMBL24680707 | 0.86 | MAPK1 (0.57) | MAPK1FYNMAPKAPK2PARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |