Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methazolamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 20/20 | 1.00 |
| ▸ | CA2 known ✓ | P00918 | 20/20 | 1.00 |
| ▸ | CA4 known ✓ | P22748 | 3/20 | 1.00 |
| ▸ | CA7 known ✓ | P43166 | 3/20 | 1.00 |
| ▸ | CA9 | Q16790 | 7/20 | 1.00 |
| ▸ | CA12 | O43570 | 3/20 | 1.00 |
| ▸ | CA3 | P07451 | 3/20 | 1.00 |
| ▸ | CA6 | P23280 | 3/20 | 1.00 |
| ▸ | CA5A | P35218 | 3/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methazolamide SCHEMBL9312473 | 1.00 | CA1 (1.00) | CA1CA2CA9CA12CA3 | |
| Methazolamide SCHEMBL13825893 | 1.00 | CA1 (1.00) | CA1CA2CA9CA12CA3 | |
| Methazolamide SCHEMBL24687 | 1.00 | CA1 (1.00) | CA1CA2CA9CA12CA3 | |
| Methazolamide SCHEMBL11042633 | 0.98 | CA1 (0.97) | CA1CA2CA9CA12CA3 | |
| Methazolamide SCHEMBL11042630 | 0.98 | CA1 (0.97) | CA1CA2CA9CA12CA3 | |
| Methazolamide SCHEMBL7037043 | 0.98 | CA1 (0.97) | CA1CA2CA9CA12CA3 | |
| Methazolamide SCHEMBL7037047 | 0.98 | CA1 (0.97) | CA1CA2CA9CA12CA3 | |
| Methazolamide SCHEMBL28556858 | 0.97 | CA1 (0.94) | CA1CA2CA9CA12CA3 | |
| Methazolamide SCHEMBL29142823 | 0.92 | CA1 (0.84) | CA1CA2CA9CA12CA3 | |
| Methazolamide SCHEMBL6258297 | 0.89 | CA1 (0.80) | CA1CA2CA9CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12395 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630599-B2 | CA2 compositions and methods for tunable regulation | OBSIDIAN THERAPEUTICS, INC. (US) | 2026-05-19 | — | — | US | claimed |
| EP-4739302-A2 | HYALURONIC ACID BASED DRUG DELIVERY SYSTEMS | Cella Therapeutics, LLC (US) | 2026-05-13 | — | — | EP | claimed |
| EP-4724839-A2 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | Mediprint Ophthalmics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4724079-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| US-20260090984-A1 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | MEDIPRINT OPHTHALMICS INC. (US) | 2026-04-02 | — | — | US | claimed |
| US-20260083709-A1 | COMBINATION PHARMACOLOGICAL INTERVENTIONS FOR MULTIPLE MECHANISMS OF OBSTRUCTIVE SLEEP APNEA | APNIMED INC DELAWARE (US) | 2026-03-26 | — | — | US | claimed |
| US-20260048096-A1 | METHODS AND COMPOSITIONS FOR PRESERVING THE RETINAL OUTER NUCLEAR LAYER (ONL), PHOTORECEPTORS, AND RETINAL THICKNESS | STEALTH BIOTHERAPEUTICS INC. (US) | 2026-02-19 | — | — | US | claimed |
| US-12551527-B2 | Drug delivery systems for treatment of infections | WAYNE STATE UNIVERSITY (US) | 2026-02-17 | — | — | US | claimed |
| EP-4691568-A2 | LOW-DOSE BRIMONIDINE COMBINATIONS AND USES THEREOF | Eye Therapies, LLC (US) | 2026-02-11 | — | — | EP | claimed |
| EP-0014642-B1 | OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF CARBONIC ANHYDRASE INHIBITORS AND S-(-)-1-(TERT-BUTYLAMINO)-3-(4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)-OXY-2-PROPANOL FOR TOPICAL APPLICATION IN THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1984-03-21 | — | — | EP | claimed |
| US-4438123-A | Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure | MERCK & CO., INC. (US) | 1984-03-20 | — | — | US | claimed |
| EP-0083779-A1 | Hyperuretic agents | Beyer, Karl H., Jr. (US) | 1983-07-20 | — | — | EP | claimed |
| EP-0036351-A2 | Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1981-09-23 | — | — | EP | claimed |
| EP-0033042-A1 | Ophthalmic inserts for lowering intraocular pressure comprising carbonic anhydrase inhibitors | MERCK & CO. INC. (US) | 1981-08-05 | — | — | EP | claimed |
| US-4221783-A | A SULFONAMIDE, POTASSIUM OR SODIUM BICARBONATE AND CITRATE, MAGNESIUM CARBONATE OR OXIDE | CENTRALA INDUSTRIALA DE MEDICAMENTE COSMETICE COLORANTI SI LACURI (RO) | 1980-09-09 | — | — | US | claimed |
| EP-0014642-A2 | Ophthalmic compositions comprising combinations of carbonic anhydrase inhibitors and S-(-)-1-(tert-butylamino)-3-(4-morpholino-1,2,5-thiadiazol-3-yl)-oxy-2-propanol for topical application in the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1980-08-20 | — | — | EP | claimed |
| US-4014334-A | Laminated osmotic system for dispensing beneficial agent | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| US-4008719-A | Osmotic system having laminar arrangement for programming delivery of active agent | ALZA CORPORATION (US) | 1977-02-22 | — | — | US | claimed |
| US-3977404-A | OSMOTIC DEVICE HAVING MICROPOROUS RESERVOIR | ALZA CORPORATION (US) | 1976-08-31 | — | — | US | claimed |