⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245799 | 0.90 | — | — | |
| SCHEMBL153092 | 0.87 | — | — | |
| SCHEMBL8728916 | 0.87 | — | — | |
| SCHEMBL1394302 | 0.87 | — | — | |
| SCHEMBL25411901 | 0.87 | — | — | |
| SCHEMBL25413484 | 0.87 | — | — | |
| SCHEMBL25412754 | 0.87 | — | — | |
| SCHEMBL25414366 | 0.87 | — | — | |
| SCHEMBL472208 | 0.87 | — | — | |
| SCHEMBL864037 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2781 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260186-B | VMAT2 inhibitor and preparation method and application thereof | 山东绿叶制药有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-112689509-B | Heterocyclic sulfonamide derivatives and pharmaceutical uses thereof | 梅特恩生物科学有限公司 | 2024-03-29 | — | — | CN | claimed |
| WO-2024064178-A1 | HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE VMAT2 INHIBITORS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2024-03-28 | — | — | WO | claimed |
| CN-117700635-A | Dispersing thickener, preparation method and application thereof | 浙江震东新材料有限公司 | 2024-03-15 | — | — | CN | claimed |
| US-20230391725-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2023-12-07 | — | — | US | claimed |
| CN-117062815-A | VMAT2 inhibitors and methods of use | 纽罗克里生物科学有限公司 | 2023-11-14 | — | — | CN | claimed |
| WO-2023178065-A2 | LIPID COMPOUNDS AND LIPID NANOPARTICLES | BROADPHARM INC. (US) | 2023-09-21 | — | — | WO | claimed |
| EP-4232153-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | Evotec International GmbH (DE) | 2023-08-30 | — | — | EP | claimed |
| EP-3880676-B1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER (US) | 2023-08-02 | — | — | EP | claimed |
| EP-4168409-A1 | VMAT2 INHIBITORS AND METHODS OF USE | Neurocrine Biosciences, Inc. (US) | 2023-04-26 | — | — | EP | claimed |
| EP-0114172-B1 | ANTI-INFLAMMATORY COMPOSITION | MERCK & CO. INC. (US) | 1987-04-29 | — | — | EP | claimed |
| EP-0163416-A2 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-12-04 | — | — | EP | claimed |
| EP-0114172-A1 | Anti-inflammatory composition | MERCK & CO. INC. (US) | 1984-08-01 | — | — | EP | claimed |
| US-4389525-A | Process for the resolution of some interphenylene 9-thia-11-oxo-12-azaprostanoic acids | MERCK & CO., INC. (US) | 1983-06-21 | — | — | US | claimed |
| US-4379792-A | Anti-inflammatory composition | MERCK & CO., INC. (US) | 1983-04-12 | — | — | US | claimed |
| EP-0001900-B1 | 9-THIA-12-AZAPROSTANOIC ACID DERIVATIVES AND COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1982-04-07 | — | — | EP | claimed |
| US-4225609-A | Interphenylene 9-thia-11-oxo-12-aza-prostanoic acids | MERCK & CO., INC. (US) | 1980-09-30 | — | — | US | claimed |
| EP-0001900-A1 | 9-Thia-12-azaprostanoic acid derivatives and compositions containing them | MERCK & CO. INC. (US) | 1979-05-16 | — | — | EP | claimed |
| US-4117014-A | PROSTAGLANDIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1978-09-26 | — | — | US | claimed |
| US-4055597-A | RENAL VASODILATORS | MERCK & CO., INC. (US) | 1977-10-25 | — | — | US | claimed |