Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24696345 | 0.92 | KDM4E (0.39) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24696375 | 0.91 | SMN1; SMN2 (0.40) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24696145 | 0.91 | SMN1; SMN2 (0.40) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24696372 | 0.87 | KDM4E (0.36) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24696347 | 0.86 | KDM4E (0.40) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24696012 | 0.86 | SMN1; SMN2 (0.42) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24696340 | 0.85 | KDM4E (0.39) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24695628 | 0.85 | SMN1; SMN2 (0.41) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24695972 | 0.85 | SMN1; SMN2 (0.41) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24695971 | 0.84 | SMN1; SMN2 (0.40) | KDM4EPOLBALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022255408-A1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUND FOR THE TREATMENT OF DERMAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2022-12-08 | — | — | WO | disclosed |