Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470258 | 0.94 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2493156 | 0.93 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2468203 | 0.91 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2466064 | 0.90 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2472021 | 0.89 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2468942 | 0.89 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2472664 | 0.88 | PIK3CA (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1822731 | 0.87 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2472630 | 0.87 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2473327 | 0.86 | PIK3CA (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575940-B1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2011-10-05 | — | — | EP | claimed |