Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.54 |
| ▸ | TUBB | P07437 | 1/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244247 | 0.92 | MEN1 (1.00) | MEN1KMT2AALDH1A1LMNAATM | |
| SCHEMBL29890124 | 0.90 | MEN1 (0.70) | MEN1KMT2AALDH1A1LMNAATM | |
| SCHEMBL89358 | 0.88 | MEN1 (0.68) | MEN1KMT2AALDH1A1LMNAATM | |
| SCHEMBL89655 | 0.88 | MEN1 (0.68) | MEN1KMT2AALDH1A1LMNAATM | |
| SCHEMBL2086693 | 0.87 | MEN1 (0.66) | MEN1KMT2AALDH1A1LMNAATM | |
| SCHEMBL2468483 | 0.83 | NPC1 (0.71) | MEN1KMT2AALDH1A1LMNAMCHR1 | |
| SCHEMBL27962667 | 0.83 | KMT2A (0.65) | MEN1KMT2AALDH1A1LMNAATM | |
| SCHEMBL27962669 | 0.83 | KMT2A (0.65) | MEN1KMT2AALDH1A1LMNAATM | |
| SCHEMBL2536771 | 0.82 | NPC1 (0.64) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL8236725 | 0.82 | MEN1 (0.59) | MEN1KMT2AALDH1A1LMNAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-B1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-05 | — | — | EP | claimed |