Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.57 |
| ▸ | JAK1 | P23458 | 7/20 | 0.57 |
| ▸ | TYK2 | P29597 | 7/20 | 0.57 |
| ▸ | JAK3 | P52333 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL141786 | 0.88 | JAK2 (0.72) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL143139 | 0.85 | JAK2 (0.53) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL13284311 | 0.85 | JAK2 (0.59) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL144073 | 0.85 | JAK2 (0.72) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL141957 | 0.80 | JAK2 (0.71) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL143497 | 0.78 | BTK (0.50) | MEN1IKBKBUSP2ALDH1A1TP53 | |
| SCHEMBL15994195 | 0.78 | JAK2 (0.49) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2469096 | 0.77 | JAK2 (0.85) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL143095 | 0.73 | MEN1 (0.49) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL139520 | 0.73 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |