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Sugi Predict / Compounds / SCHEMBL24701270

SCHEMBL24701270

SCHEMBL24701270

Cc1cc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)ccc1N

nearest known ligand 0.79

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 14/20 0.79
▸ GSPT1 P15170 5/20 0.79
▸ DDB1 Q16531 3/20 0.79
▸ IKZF3 Q9UKT9 1/20 0.79
▸ CYP2C19 P33261 1/20 0.57
▸ KCNH2 Q12809 1/20 0.57
▸ CSNK1A1 P48729 6/20 0.57
▸ IKZF2 Q9UKS7 10/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL62187 0.93 CRBN (0.82) CRBNGSPT1DDB1IKZF3CYP2C19
SCHEMBL1413700 0.93 CRBN (0.86) CRBNGSPT1DDB1IKZF3CYP2C19
SCHEMBL1403650 0.92 CRBN (0.79) CRBNGSPT1DDB1IKZF3CYP2C19
SCHEMBL61816 0.91 CRBN (0.81) CRBNGSPT1DDB1IKZF3CYP2C19
SCHEMBL23900555 0.90 CRBN (0.82) CRBNGSPT1DDB1IKZF3CYP2C19
SCHEMBL61099 0.89 CRBN (0.83) CRBNGSPT1DDB1IKZF3CYP2C19
SCHEMBL61785 0.89 CRBN (0.75) CRBNGSPT1DDB1IKZF3CYP2C19
SCHEMBL1413606 0.89 CRBN (0.80) CRBNGSPT1DDB1IKZF3CYP2C19
SCHEMBL62578 0.89 CRBN (0.80) CRBNGSPT1DDB1IKZF3CYP2C19
SCHEMBL29360673 0.89 CRBN (1.00) CRBNGSPT1DDB1IKZF3CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022254377-A1 NEODEGRADER-ANTI-CD33 ANTIBODY CONJUGATES ORUM THERAPEUTICS, INC. (KR) 2022-12-08 — — WO disclosed