Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 9/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 4/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2469661 | 0.92 | STAT3 (0.49) | STAT3L3MBTL1PDK1PTPN11PTPRO | |
| SCHEMBL2469349 | 0.80 | STAT3 (0.52) | STAT3PTPN11PTPROPLK1 | |
| SCHEMBL2468945 | 0.79 | STAT3 (0.51) | STAT3PTPN11PTPROKAT8 | |
| SCHEMBL2470827 | 0.78 | STAT3 (0.50) | STAT3PTPN11PTPROKLK1 | |
| SCHEMBL2469748 | 0.77 | STAT3 (0.46) | STAT3PTPN11PTPROPLK1KAT8 | |
| SCHEMBL2467356 | 0.72 | STAT3 (0.56) | STAT3PDK1 | |
| SCHEMBL6031698 | 0.70 | TP53 (0.40) | L3MBTL1PLK1 | |
| SCHEMBL2470089 | 0.70 | STAT3 (0.67) | STAT3PDK1PTPN11PTPROPLK1 | |
| SCHEMBL2472681 | 0.70 | STAT3 (0.64) | STAT3PDK1PTPN11PTPROPLK1 | |
| SCHEMBL2467885 | 0.69 | STAT3 (0.52) | STAT3PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656139-B1 | ARYL DICARBOXAMIDES | MERCK SERONO SA (CH) | 2011-10-05 | — | — | EP | claimed |