Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 2/20 | 0.40 |
| ▸ | SKP1 | P63208 | 2/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12269591 | 0.87 | CKS1B (0.41) | MAP4K4CKS1BSKP1SKP2TLR9 | |
| SCHEMBL2465903 | 0.86 | PTPN11 (0.42) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL2468758 | 0.86 | P2RY12 (0.31) | — | |
| SCHEMBL12269550 | 0.83 | CKS1B (0.41) | MAP4K4CKS1BSKP1SKP2TLR9 | |
| SCHEMBL2401989 | 0.81 | NR1H2 (0.42) | MAP4K4CKS1BSKP1SKP2TLR9 | |
| SCHEMBL2401992 | 0.81 | NR1H2 (0.42) | MAP4K4CKS1BSKP1SKP2TLR9 | |
| SCHEMBL2401136 | 0.78 | CKS1B (0.42) | MAP4K4CKS1BSKP1SKP2TLR9 | |
| SCHEMBL2401143 | 0.78 | CKS1B (0.42) | MAP4K4CKS1BSKP1SKP2TLR9 | |
| SCHEMBL12269558 | 0.78 | CKS1B (0.42) | MAP4K4CKS1BSKP1SKP2TLR9 | |
| SCHEMBL2402337 | 0.77 | MAP4K4 (0.52) | MAP4K4CKS1BSKP1SKP2TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545058-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | Kalypsys, Inc. (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112766-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-09-15 | — | — | WO | disclosed |