Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 7/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | DCK | P27707 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30856787 | 1.00 | ABL1 (0.38) | ABL1SCN9AFEN1ALOX5APPDE2A | |
| SCHEMBL24708126 | 0.77 | SCN9A (0.33) | SCN9AFEN1ALOX5APDCK | |
| SCHEMBL30856733 | 0.77 | SCN9A (0.33) | SCN9AFEN1ALOX5APDCK | |
| SCHEMBL18983023 | 0.73 | MKNK2 (0.41) | PDE2APDE10AMKNK2 | |
| SCHEMBL16801919 | 0.73 | MKNK2 (0.41) | PDE2APDE10AMKNK2 | |
| SCHEMBL18983025 | 0.73 | MKNK2 (0.41) | PDE2APDE10AMKNK2 | |
| SCHEMBL16801745 | 0.73 | MKNK2 (0.41) | PDE2APDE10AMKNK2 | |
| SCHEMBL16801342 | 0.73 | MKNK2 (0.41) | PDE2APDE10AMKNK2 | |
| SCHEMBL14881383 | 0.72 | LRRK2 (0.46) | SCN9ADCK | |
| SCHEMBL14879950 | 0.72 | LRRK2 (0.46) | SCN9ADCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |