Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981948 | 0.85 | KDM4E (0.39) | KDM4EGMNNUSP2ALDH1A1LMNA | |
| SCHEMBL20902791 | 0.84 | KDM4E (0.37) | KDM4EGMNNUSP2ALDH1A1LMNA | |
| SCHEMBL22793509 | 0.84 | KDM4E (0.32) | KDM4EGMNNUSP2ALDH1A1LMNA | |
| SCHEMBL22662448 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1CYP2C19TDP1 | |
| SCHEMBL19400374 | 0.84 | KDM4E (0.32) | KDM4ELMNAALOX15BLMPMP22 | |
| SCHEMBL7083891 | 0.80 | KDM4E (0.36) | KDM4EGMNNUSP2ALDH1A1LMNA | |
| SCHEMBL960674 | 0.79 | KDM4E (0.40) | KDM4EGMNNUSP2ALDH1A1LMNA | |
| SCHEMBL16280996 | 0.79 | KDM4E (0.42) | KDM4EGMNNUSP2ALDH1A1LMNA | |
| SCHEMBL22662460 | 0.78 | KDM4E (0.30) | KDM4ETDP1 | |
| SCHEMBL14094680 | 0.78 | KDM4E (0.44) | KDM4ELMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261221-A1 | NON-PEPTIDE TARGETED THERAPEUTICS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2022-12-15 | — | — | WO | disclosed |