Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Simvastatin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR known ✓ | P04035 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | PGR | P06401 | 3/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 3/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 3/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 3/20 | 1.00 |
| ▸ | HTR2B | P41595 | 3/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Simvastatin SCHEMBL7361654 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 | |
| Simvastatin SCHEMBL12573746 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 | |
| Simvastatin SCHEMBL5672857 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 | |
| Simvastatin SCHEMBL13934499 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 | |
| Simvastatin SCHEMBL24048980 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 | |
| Simvastatin SCHEMBL5506127 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 | |
| Simvastatin SCHEMBL23423222 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 | |
| Simvastatin SCHEMBL14601463 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 | |
| Simvastatin SCHEMBL4455910 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 | |
| Simvastatin SCHEMBL21340589 | 1.00 | HMGCR (1.00) | HMGCRCYP3A4TSHRKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 143705 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144789-A1 | WOUND TREATMENTS AND COMPOSITIONS | CMPD LICENSING, LLC (US) | 2026-05-28 | — | — | US | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-117085011-B | Pharmaceutical composition of ezetimibe and HMG-CoA reductase inhibitor | ZHEJIANG HISUN PHARMACEUTICAL CO.,LTD. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-12640239-B2 | Functional biomarkers for statin therapy in age-related macular degeneration (AMD) | APELIOTUS TECHNOLOGIES, INC. (US) | 2026-05-26 | — | — | US | claimed |
| US-12636273-B2 | Compositions for pathogenesis-directed therapy and treatments of skin diseases and disorders | YALE UNIVERSITY (US) | 2026-05-26 | — | — | US | claimed |
| CN-122075699-A | Application of calcium activated chloride channel AN01/TMEM16A in preventing and treating atherosclerosis | — | 2026-05-26 | — | — | CN | claimed |
| EP-4745160-A1 | METHOD FOR TREATING OR PREVENTING CHOLESTEROL-RELATED DISEASES USING PCSK9 INHIBITOR | Salubris (Chengdu) Biotech Co., Ltd. (CN) | 2026-05-20 | — | — | EP | claimed |
| US-20260124215-A1 | METHODS OF TREATMENT OF INTESTINAL INFECTIONS | THE FRANCIS CRICK INST LIMITED (GB) | 2026-05-07 | — | — | US | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-20260115145-A1 | Method for Enhancing Drug Solubility and Preparing a Drug Composite Material with Enhanced Solubility | PHARMAEASE TECH LTD (CN) | 2026-04-30 | — | — | US | claimed |
| US-4613990-A | Radiotelephone transmission power control | AT&T BELL LABORATORIES (US) | 1986-09-23 | — | — | US | claimed |
| US-4607289-A | Facsimile transceiver capable of storing and relaying data | RICOH COMPANY, LTD. (JP) | 1986-08-19 | — | — | US | claimed |
| US-4566624-A | Mass wave soldering system | HOLLIS AUTOMATION, INC. (US) | 1986-01-28 | — | — | US | claimed |
| EP-0158867-A2 | Arrangement for intermittent fuel injection | Atlas Fahrzeugtechnik GmbH (DE) | 1985-10-23 | — | — | EP | claimed |
| EP-0144290-A2 | Substituted ethylenediamine derivatives | CIBA-GEIGY AG (CH) | 1985-06-12 | — | — | EP | claimed |
| EP-0143746-A2 | 5-Amino 4-hydroxy-valeryl-substituted derivatives | CIBA-GEIGY AG (CH) | 1985-06-05 | — | — | EP | claimed |
| EP-0048149-B1 | NOVEL ANTIBIOTICS, DERIVATIVES THEREOF, PROCESSES FOR THEIR EXTRACTION, AND COMPOSITIONS CONTAINING THEM | University of Illinois Foundation (US) | 1983-11-30 | — | — | EP | claimed |
| US-4391210-A | Tag attaching machine | TOMOE SPECIAL MACHINE CO., LTD. (JP) | 1983-07-05 | — | — | US | claimed |
| US-4342986-A | Central station alarm reporting system | HONEYWELL INC. (US) | 1982-08-03 | — | — | US | claimed |
| US-4042298-A | Document filming camera | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1977-08-16 | — | — | US | claimed |