Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CDK14 | O94921 | 13/20 | 0.46 |
| ▸ | CCNY | Q8ND76 | 13/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CASK | O14936 | 1/20 | 0.42 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | MAK | P20794 | 1/20 | 0.42 |
| ▸ | CDK11B | P21127 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24709961 | 0.89 | POLB (0.46) | POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL22594205 | 0.88 | CDK14 (0.48) | POLBCDK14CCNYCCNT1CDK9 | |
| Bromide SCHEMBL22582181 | 0.87 | CDK14 (0.47) | POLBCDK14CCNYCCNT1CDK9 | |
| SCHEMBL24757744 | 0.87 | CDK14 (0.49) | CDK14CCNYCCNT1CDK9CDK5 | |
| SCHEMBL24333895 | 0.85 | CDK5 (0.48) | CDK14CCNYCCNT1CDK9CDK5 | |
| SCHEMBL22582168 | 0.85 | CDK14 (0.43) | POLBCDK14CCNYCCNT1CDK9 | |
| SCHEMBL8212911 | 0.85 | CCNT1 (0.48) | CDK14CCNYCCNT1CDK9CDK5 | |
| SCHEMBL1286714 | 0.84 | CDK5 (0.53) | CDK14CCNYCCNT1CDK9CDK5 | |
| SCHEMBL22582205 | 0.84 | CDK5 (0.46) | CDK14CCNYCCNT1CDK9CDK5 | |
| SCHEMBL24710274 | 0.84 | CDK14 (0.49) | CDK14CCNYCCNT1CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261220-A1 | PROTEOLYSIS TARGETING CHIMERAS AND METHODS OF USE THEREOF | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2022-12-15 | — | — | WO | disclosed |