Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 15/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30277891 | 1.00 | MAPK1 (0.64) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22729058 | 0.86 | MAPK1 (0.66) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL29676727 | 0.83 | MAPK1 (0.62) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL28764345 | 0.83 | MAPK1 (0.62) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL25306392 | 0.83 | MAPK1 (0.54) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24650700 | 0.80 | MAPK1 (0.57) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24650690 | 0.80 | MAPK1 (0.57) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL29730384 | 0.78 | MAPK1 (1.00) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL25306667 | 0.77 | MAPK1 (0.62) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL29220626 | 0.77 | MAPK1 (0.54) | MAPK1HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117881676-A | Methods for preparing ERK inhibitors | 大塚制药株式会社 | 2024-04-12 | — | — | CN | disclosed |
| WO-2022259222-A1 | PROCESS FOR PREPARING AN ERK INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2022-12-15 | — | — | WO | disclosed |