Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 7/20 | 0.67 |
| ▸ | KIT | P10721 | 7/20 | 0.67 |
| ▸ | FLT3 | P36888 | 7/20 | 0.67 |
| ▸ | CSF1R | P07333 | 5/20 | 0.67 |
| ▸ | TEK | Q02763 | 5/20 | 0.67 |
| ▸ | FLT4 | P35916 | 5/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.67 |
| ▸ | LCK | P06239 | 4/20 | 0.67 |
| ▸ | GSK3B | P49841 | 3/20 | 0.67 |
| ▸ | AURKA | O14965 | 3/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.67 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.67 |
| ▸ | SRC | P12931 | 3/20 | 0.67 |
| ▸ | ABL1 | P00519 | 3/20 | 0.67 |
| ▸ | FYN | P06241 | 3/20 | 0.67 |
| ▸ | LYN | P07948 | 3/20 | 0.67 |
| ▸ | BLK | P51451 | 3/20 | 0.67 |
| ▸ | GSK3A | P49840 | 2/20 | 0.67 |
| ▸ | RET | P07949 | 2/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000858 | 1.00 | FLT1 (0.67) | FLT1KITFLT3CSF1RTEK | |
| SCHEMBL30155208 | 0.89 | RET (0.71) | FLT1KITFLT3CSF1RTEK | |
| SCHEMBL24711416 | 0.86 | RET (0.52) | FLT1KITFLT3CSF1RTEK | |
| SCHEMBL31000864 | 0.85 | FLT3 (0.62) | FLT1KITFLT3CSF1RTEK | |
| SCHEMBL24710556 | 0.85 | FLT3 (0.62) | FLT1KITFLT3CSF1RTEK | |
| SCHEMBL30155268 | 0.83 | RET (0.64) | FLT1KITFLT3CSF1RTEK | |
| SCHEMBL24710549 | 0.82 | RET (0.63) | FLT1KITFLT3CSF1RTEK | |
| SCHEMBL30155426 | 0.82 | RET (0.63) | FLT1KITFLT3CSF1RTEK | |
| SCHEMBL24710786 | 0.82 | FLT1 (0.71) | FLT1KITFLT3CSF1RTEK | |
| SCHEMBL24710551 | 0.82 | RET (0.62) | FLT1KITFLT3CSF1RTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261352-A1 | PERFLUOROALKANE SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDIN AND PYRROLO[2,3-D]PYRIMIDIN COMPOUNDS AND USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-12-15 | — | — | WO | disclosed |