Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.89 |
| ▸ | KDR | P35968 | 15/20 | 0.57 |
| ▸ | FLT1 | P17948 | 5/20 | 0.57 |
| ▸ | KIT | P10721 | 4/20 | 0.57 |
| ▸ | FLT4 | P35916 | 4/20 | 0.57 |
| ▸ | TEK | Q02763 | 4/20 | 0.57 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 10/20 | 0.55 |
| ▸ | EGFR | P00533 | 10/20 | 0.55 |
| ▸ | SRC | P12931 | 9/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.55 |
| ▸ | PRKDC | P78527 | 9/20 | 0.55 |
| ▸ | HCK | P08631 | 8/20 | 0.55 |
| ▸ | MTOR | P42345 | 8/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000867 | 1.00 | RET (0.89) | RETKDRFLT1KITFLT4 | |
| SCHEMBL24710707 | 0.95 | RET (0.86) | RETKDRFLT1KITFLT4 | |
| SCHEMBL24710703 | 0.94 | RET (0.85) | RETKDRFLT1KITFLT4 | |
| SCHEMBL30155251 | 0.94 | RET (0.88) | RETKDRFLT1KITFLT4 | |
| SCHEMBL24710708 | 0.94 | RET (0.88) | RETKDRFLT1KITFLT4 | |
| SCHEMBL29378701 | 0.94 | RET (1.00) | RETKDRFLT1KITFLT4 | |
| SCHEMBL14985438 | 0.94 | RET (1.00) | RETKDRFLT1KITFLT4 | |
| Trifluoroacetic Acid SCHEMBL30155413 | 0.92 | RET (0.81) | RETKDRFLT1KITFLT4 | |
| SCHEMBL24710704 | 0.92 | RET (0.84) | RETKDRFLT1KITFLT4 | |
| SCHEMBL30155406 | 0.92 | RET (0.84) | RETKDRFLT1KITFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261352-A1 | PERFLUOROALKANE SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDIN AND PYRROLO[2,3-D]PYRIMIDIN COMPOUNDS AND USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-12-15 | — | — | WO | disclosed |