Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.41 |
| ▸ | ACLY | P53396 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437903 | 0.85 | HTT (0.44) | RECQLKDM4EHTTTP53ALDH1A1 | |
| SCHEMBL5941108 | 0.76 | KMT2A (0.48) | KDM4EHTTALDH1A1LMNAMAPT | |
| SCHEMBL21917353 | 0.73 | HTT (0.50) | RECQLKDM4ECACNA1BAPBA1HTT | |
| SCHEMBL3527060 | 0.72 | HTT (0.68) | RECQLHTTADORA2AADORA1MAP2K1 | |
| SCHEMBL21917261 | 0.72 | EPHX2 (0.40) | RECQLCACNA1BAPBA1HTTALDH1A1 | |
| SCHEMBL21917576 | 0.71 | HTT (0.45) | RECQLKDM4ECACNA1BAPBA1HTT | |
| SCHEMBL2437350 | 0.71 | KDM4E (0.52) | RECQLKDM4EHTTADORA2AADORA1 | |
| SCHEMBL2469097 | 0.71 | HTT (0.43) | RECQLKDM4ECACNA1BAPBA1HTT | |
| SCHEMBL1230231 | 0.71 | KDM4E (0.52) | RECQLKDM4ECACNA1BAPBA1HTT | |
| SCHEMBL5941099 | 0.70 | HTT (0.64) | RECQLHTTADORA2AADORA1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6989451-B2 | Substituted isothiazole compounds are useful for treating the diseases associated with abnormality in protein kinases(especially MAP kinases) | VALEANT RESEARCH & DEVELOPMENT (US) | 2006-01-24 | — | — | US | claimed |
| EP-2362909-A2 | MAMMALIAN GENES INVOLVED IN INFECTION | Zirus, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2010039778-A2 | MAMMALIAN GENES INVOLVED IN INFECTION | Zirus, Inc. (US) | 2010-04-08 | — | — | WO | disclosed |
| US-6989451-B2 | Substituted isothiazole compounds are useful for treating the diseases associated with abnormality in protein kinases(especially MAP kinases) | VALEANT RESEARCH & DEVELOPMENT (US) | 2006-01-24 | — | — | US | disclosed |
| US-20040039037-A1 | Heterocyclic compounds and uses thereof | VALEANT PHARMA POLAND SPOLKA Z ORGANICZONA ODPOWIEDZIALNOSCIA (PL) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039037-A1 | Heterocyclic compounds and uses thereof | MAP3K1, MAP3K20, MAP4K2 | RECQL 3054/4885KDM4E 2204/4885APAF1 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.