Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 11/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.56 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.51 |
| ▸ | MTOR | P42345 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | ECE1 | P42892 | 1/20 | 0.50 |
| ▸ | XRCC6 | P12956 | 1/20 | 0.49 |
| ▸ | XRCC5 | P13010 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.49 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887282 | 0.89 | PIK3CA (0.47) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL23887233 | 0.88 | PRKDC (0.50) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL23887352 | 0.85 | PIK3CA (0.59) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL23887059 | 0.84 | PIK3CA (0.51) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL23887297 | 0.84 | PIK3CA (0.42) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL23887327 | 0.83 | PIK3CA (0.44) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL13449184 | 0.82 | PRKDC (0.58) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL23887074 | 0.82 | ATM (0.44) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL23887347 | 0.81 | PIK3CA (0.54) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1638958 | 0.81 | PIK3CA (0.53) | PRKDCPIK3CAPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022164812-A1 | PHOSPHOINOSITIDE 3 KINASE BETA INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | GEODE THERAPEUTICS INC. (US) | 2022-08-04 | — | — | WO | disclosed |