Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | MAP4K1 | Q92918 | 12/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716041 | 0.95 | LRRK2 (0.56) | LRRK2MAP4K1ALKAXL | |
| SCHEMBL24716358 | 0.86 | LRRK2 (0.54) | LRRK2MAP4K1ALKMAPK3 | |
| SCHEMBL29869062 | 0.86 | LRRK2 (0.54) | LRRK2MAP4K1ALKMAPK3 | |
| SCHEMBL24716047 | 0.84 | MAP4K1 (0.54) | MAP4K1ALKAXL | |
| SCHEMBL24716908 | 0.83 | MAP4K1 (0.53) | MAP4K1ALKAXL | |
| SCHEMBL24716378 | 0.83 | MAP4K1 (0.53) | MAP4K1ALKAXL | |
| SCHEMBL24716377 | 0.83 | ALK (0.60) | MAP4K1ALKAXL | |
| SCHEMBL24715921 | 0.83 | MAP4K1 (0.72) | MAP4K1ALK | |
| SCHEMBL24716360 | 0.82 | ALK (0.73) | ALK | |
| SCHEMBL24716046 | 0.82 | MAP4K1 (0.52) | MAP4K1ALKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |