Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 6/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306365 | 1.00 | CXCR4 (0.41) | CXCR4OPRL1KCNH2OPRM1MEN1 | |
| SCHEMBL2472885 | 0.89 | CXCR4 (0.40) | CXCR4OPRL1 | |
| SCHEMBL8304668 | 0.88 | CXCR4 (0.41) | CXCR4OPRL1KCNH2OPRM1 | |
| SCHEMBL2472736 | 0.88 | CXCR4 (0.41) | CXCR4OPRL1KCNH2OPRM1 | |
| SCHEMBL8301800 | 0.88 | CXCR4 (0.41) | CXCR4OPRL1KCNH2OPRM1 | |
| SCHEMBL2475579 | 0.88 | CXCR4 (0.41) | CXCR4OPRL1KCNH2OPRM1 | |
| SCHEMBL8301709 | 0.87 | CXCR4 (0.40) | CXCR4OPRL1MEN1KMT2A | |
| SCHEMBL11904356 | 0.87 | CXCR4 (0.34) | CXCR4OPRL1KCNH2 | |
| SCHEMBL2472848 | 0.86 | CXCR4 (0.39) | CXCR4OPRL1KCNH2 | |
| SCHEMBL8304208 | 0.85 | CXCR4 (0.41) | CXCR4OPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615633-B1 | CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY | GENZYME CORP (US) | 2012-08-15 | — | — | EP | claimed |
| EP-2374804-A1 | Chemokine receptor binding heterocyclic compounds with enhanced efficacy | Genzyme Corporation (US) | 2011-10-12 | — | — | EP | claimed |
| EP-1615633-B1 | CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY | GENZYME CORP (US) | 2012-08-15 | — | — | EP | disclosed |
| EP-2374804-A1 | Chemokine receptor binding heterocyclic compounds with enhanced efficacy | Genzyme Corporation (US) | 2011-10-12 | — | — | EP | disclosed |
| US-7550484-B2 | Chemokine receptor binding heterocyclic compounds with enhanced efficacy | GENZYME CORPORATION (US) | 2009-06-23 | — | — | US | disclosed |