Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29831685 | 0.88 | MAPT (0.43) | MAPTMEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL23330720 | 0.88 | MAPT (0.43) | MAPTMEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL29831249 | 0.83 | CYP2C19 (0.47) | MAPTMEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL23330455 | 0.83 | CYP2C19 (0.47) | MAPTMEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL24932419 | 0.76 | MCL1 (0.44) | CYP2C19HDAC8HDAC6PPARGPPARA | |
| SCHEMBL29831544 | 0.73 | MCL1 (0.43) | KMT2ACYP2C19CYP1A2HDAC8HDAC6 | |
| SCHEMBL23300704 | 0.73 | MCL1 (0.43) | KMT2ACYP2C19CYP1A2HDAC8HDAC6 | |
| SCHEMBL24932904 | 0.72 | MEN1 (0.31) | MAPTMEN1ALDH1A1HPGDMAPK1 | |
| SCHEMBL23330544 | 0.71 | POLQ (0.37) | MAPTMEN1KMT2ANPSR1HDAC8 | |
| SCHEMBL23300727 | 0.71 | PARP14 (0.46) | MAPTMEN1KMT2ANPSR1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4053124-A1 | FIVE-MEMBERED HETEROCYCLIC OXOCARBOXYLIC ACID COMPOUND AND MEDICAL USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2022-09-07 | — | — | EP | disclosed |