Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 15/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 15/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24722486 | 0.86 | PDCD1 (0.46) | PDCD1CD274 | |
| SCHEMBL24722487 | 0.82 | PDCD1 (0.45) | PDCD1CD274 | |
| SCHEMBL23202610 | 0.82 | PARP1 (0.43) | PDCD1CD274PARP1TNKS2PARP2 | |
| SCHEMBL24758745 | 0.81 | PDCD1 (0.57) | PDCD1CD274 | |
| SCHEMBL23198767 | 0.81 | PARP1 (0.44) | PDCD1CD274PARP1TNKS2PARP2 | |
| SCHEMBL24722531 | 0.79 | PDCD1 (0.60) | PDCD1CD274 | |
| SCHEMBL23202633 | 0.78 | PARP1 (0.39) | PDCD1CD274PARP1TNKS2PARP2 | |
| SCHEMBL23202652 | 0.77 | PARP1 (0.43) | PARP1TNKS2PARP2C5AR1RAF1 | |
| SCHEMBL24722760 | 0.77 | PDCD1 (0.51) | PDCD1CD274 | |
| SCHEMBL20293091 | 0.75 | PDCD1 (0.64) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4043461-A1 | COMPOUND AS SMALL MOLECULE INHIBITOR PD-1/PD-L1 AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2022-08-17 | — | — | EP | disclosed |