Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.80 |
| ▸ | AURKA | O14965 | 5/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.69 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.69 |
| ▸ | LCK | P06239 | 4/20 | 0.69 |
| ▸ | LYN | P07948 | 4/20 | 0.69 |
| ▸ | RET | P07949 | 4/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.69 |
| ▸ | FLT1 | P17948 | 4/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.69 |
| ▸ | AXL | P30530 | 4/20 | 0.69 |
| ▸ | FLT3 | P36888 | 4/20 | 0.69 |
| ▸ | FRK | P42685 | 4/20 | 0.69 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.69 |
| ▸ | CLK2 | P49760 | 4/20 | 0.69 |
| ▸ | BLK | P51451 | 4/20 | 0.69 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3530946 | 0.89 | KDR (1.00) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3532906 | 0.89 | KDR (0.77) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3530439 | 0.88 | KDR (1.00) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3531078 | 0.87 | KDR (1.00) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3530438 | 0.85 | KDR (0.81) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3531429 | 0.85 | KDR (0.81) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3534864 | 0.85 | KDR (1.00) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3527915 | 0.84 | KDR (1.00) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3534352 | 0.84 | KDR (1.00) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3381755 | 0.83 | KDR (0.68) | KDRAURKAAURKBROCK2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373662-A2 | THIENO[3,2-C]PYRIDINE DERIVATIVES AS KINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010065825-A2 | KINASE INHIBITORS WITH IMPROVED CYP SAFETY PROFILE | ABBOTT LABORATORIES (US) | 2010-06-10 | — | — | WO | disclosed |