Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | UGT2B17 | O75795 | 2/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3692441 | 0.84 | UGT2B17 (0.38) | HTR7HTR2BTMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL24722919 | 0.83 | DAO (0.34) | DAOMAPK1ALDH1A1CHRM4LIPE | |
| SCHEMBL24723084 | 0.83 | DAO (0.34) | DAOMAPK1CHRM4LIPE | |
| SCHEMBL8004809 | 0.79 | PSMB5 (0.44) | HTR7HTR2BTMEM97SIGMAR1UGT2B17 | |
| SCHEMBL1452171 | 0.77 | PSMB5 (0.47) | MAPK1UGT2B17PSMB5 | |
| SCHEMBL2724194 | 0.77 | PSMB5 (0.47) | MAPK1UGT2B17PSMB5 | |
| SCHEMBL24722863 | 0.76 | DAO (0.33) | DAOCHRM4 | |
| SCHEMBL27347198 | 0.76 | HTR2C (0.37) | DAOMAPK1ALDH1A1SYK | |
| SCHEMBL15517754 | 0.75 | UGT2B17 (0.39) | DAOMAPK1ALDH1A1MAPTUGT2B17 | |
| SCHEMBL5584576 | 0.74 | PSMB5 (0.34) | HTR7HTR2BTMEM97SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022166920-A1 | PYRROLOPYRIDAZINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2022-08-11 | — | — | WO | disclosed |