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Fosclevudine Alafenamide

Fosclevudine Alafenamide

SCHEMBL24723318

Cc1cn([C@H]2OC(COP(=O)(N[C@@H](C)C(=O)OC(C)C)Oc3ccccc3)[C@H](O)[C@H]2F)c(=O)[nH]c1=O

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 2/20 0.59
▸ CYP2C9 P11712 2/20 0.59
▸ BTN3A1 O00481 1/20 0.40
▸ P2RY6 Q15077 3/20 0.40
▸ P2RY14 Q15391 2/20 0.40
▸ P2RY2 P41231 2/20 0.40
▸ NT5E P21589 1/20 0.39
▸ TYMS P04818 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fosclevudine Alafenamide SCHEMBL21577294 1.00 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14
Fosclevudine Alafenamide SCHEMBL19825437 1.00 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14
Fosclevudine Alafenamide SCHEMBL17859274 1.00 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14
Fosclevudine Alafenamide SCHEMBL29462222 1.00 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14
Fosclevudine Alafenamide SCHEMBL24737195 1.00 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14
Fosclevudine Alafenamide SCHEMBL17859276 1.00 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14
Fosclevudine Alafenamide SCHEMBL17859295 1.00 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14
Fosclevudine Alafenamide SCHEMBL21577296 1.00 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14
SCHEMBL23720991 0.94 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14
SCHEMBL25574812 0.94 CYP3A4 (0.59) CYP3A4CYP2C9BTN3A1P2RY6P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022261046-A1 COMPOSITIONS AND METHODS OF TREATING HEPATITIS D AND HEPATITIS B/HEPATITIS D CO-INFECTIONS WITH PHOSPHORAMIDATE CLEVUDINE PRODRUGS Antios Therapeutics, Inc. (US) 2022-12-15 — — WO disclosed