Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247681 | 0.92 | PIK3CA (0.45) | PIK3CAPIK3CDMAPTMTORPIK3CB | |
| SCHEMBL246539 | 0.91 | PIK3CA (0.51) | PIK3CAPIK3CDMTORPIK3CB | |
| SCHEMBL247193 | 0.90 | PIK3CA (0.45) | PIK3CAPIK3CDMAPTMTOR | |
| SCHEMBL248451 | 0.90 | PIK3CA (0.51) | PIK3CAPIK3CDMTORPIK3CB | |
| SCHEMBL14840540 | 0.90 | PIK3CA (0.43) | PIK3CAPIK3CDMTORPIK3CB | |
| SCHEMBL249015 | 0.89 | PIK3CA (0.51) | PIK3CAPIK3CDMTORPIK3CB | |
| SCHEMBL248614 | 0.89 | PIK3CA (0.51) | PIK3CAPIK3CD | |
| SCHEMBL246549 | 0.88 | PIK3CA (0.47) | PIK3CAPIK3CDMTOR | |
| SCHEMBL253321 | 0.88 | PIK3CA (0.43) | PIK3CAPIK3CDMTORPIK3CB | |
| SCHEMBL248910 | 0.87 | PIK3CA (0.51) | PIK3CAPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588471-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |