Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 15/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | USP1 | O94782 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17797974 | 0.91 | BRD4 (0.53) | BRD4CYP1A2TSHRALDH1A1CYP3A4 | |
| SCHEMBL29920781 | 0.91 | BRD4 (0.53) | BRD4CYP1A2TSHRALDH1A1CYP3A4 | |
| SCHEMBL17798167 | 0.90 | BRD4 (0.53) | BRD4CYP1A2TSHRALDH1A1CYP3A4 | |
| SCHEMBL29920673 | 0.90 | BRD4 (0.53) | BRD4CYP1A2TSHRALDH1A1CYP3A4 | |
| SCHEMBL24728185 | 0.88 | BRD4 (0.51) | BRD4CYP1A2TSHRALDH1A1CYP3A4 | |
| SCHEMBL17798002 | 0.88 | BRD4 (0.54) | BRD4CYP1A2TSHRALDH1A1CYP3A4 | |
| SCHEMBL29921081 | 0.88 | BRD4 (0.54) | BRD4CYP1A2TSHRALDH1A1CYP3A4 | |
| SCHEMBL29921120 | 0.87 | BRD4 (0.50) | BRD4CYP1A2TSHRALDH1A1CYP3A4 | |
| SCHEMBL17798053 | 0.87 | BRD4 (0.50) | BRD4CYP1A2TSHRALDH1A1CYP3A4 | |
| SCHEMBL17798028 | 0.86 | BRD4 (0.49) | BRD4CYP1A2TSHRALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3674300-B1 | NOVEL BICYCLIC BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LTD (CA) | 2022-10-12 | — | — | EP | disclosed |