Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | TOP1 | P11387 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | SCD | O00767 | 2/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29947576 | 1.00 | NPC1 (0.53) | NPC1RAB9AKDM4ENFKB1HTT | |
| SCHEMBL24729347 | 0.90 | HSD17B10 (0.64) | NPC1RAB9AKDM4ENFKB1HTT | |
| SCHEMBL29947591 | 0.90 | HSD17B10 (0.64) | NPC1RAB9AKDM4ENFKB1HTT | |
| SCHEMBL24729516 | 0.87 | NPC1 (0.54) | NPC1RAB9AKDM4ENFKB1HTT | |
| SCHEMBL29947476 | 0.85 | HSD17B10 (0.50) | NPC1RAB9AKDM4ENFKB1HTT | |
| SCHEMBL24729247 | 0.85 | HSD17B10 (0.50) | NPC1RAB9AKDM4ENFKB1HTT | |
| SCHEMBL29947662 | 0.84 | HTT (0.61) | NPC1RAB9AKDM4EHTTHSD17B10 | |
| SCHEMBL24729368 | 0.84 | HTT (0.61) | NPC1RAB9AKDM4EHTTHSD17B10 | |
| SCHEMBL24729361 | 0.82 | NPC1 (0.61) | NPC1RAB9AKDM4ENFKB1HTT | |
| SCHEMBL24730598 | 0.82 | NPC1 (0.53) | NPC1RAB9AKDM4ENFKB1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022240213-A1 | NOVEL BENZOTHIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF FOR PREVENTION OR TREATMENT OF LIVER DISEASE | 에이치케이이노엔 주식회사 | 2022-11-17 | — | — | WO | disclosed |