Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.37 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29926995 | 1.00 | KLKB1 (0.37) | KLKB1F11F2 | |
| SCHEMBL24729593 | 0.86 | KLKB1 (0.39) | KLKB1F2 | |
| SCHEMBL29958151 | 0.84 | KLKB1 (0.39) | KLKB1F11 | |
| SCHEMBL27033946 | 0.84 | KLKB1 (0.39) | KLKB1F11 | |
| SCHEMBL29957885 | 0.83 | KLKB1 (0.39) | KLKB1F11F2 | |
| SCHEMBL24729610 | 0.83 | F2 (0.44) | KLKB1F2 | |
| SCHEMBL27033656 | 0.83 | KLKB1 (0.39) | KLKB1F11F2 | |
| SCHEMBL24729494 | 0.83 | KLKB1 (0.39) | KLKB1 | |
| SCHEMBL24739069 | 0.82 | KLKB1 (0.38) | KLKB1F11F2 | |
| SCHEMBL24729591 | 0.77 | KLKB1 (0.39) | KLKB1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |