Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.71 |
| ▸ | FLT1 | P17948 | 3/20 | 0.71 |
| ▸ | FLT4 | P35916 | 3/20 | 0.71 |
| ▸ | RET | P07949 | 1/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.71 |
| ▸ | KIT | P10721 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2466794 | 0.92 | KDR (0.60) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL278840 | 0.89 | KDR (0.78) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL12634039 | 0.87 | KDR (0.76) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2437405 | 0.87 | KDR (0.73) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL273148 | 0.85 | KDR (0.74) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2472795 | 0.84 | KDR (0.80) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2470812 | 0.84 | KDR (0.75) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL12671018 | 0.84 | KDR (0.77) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2466583 | 0.83 | KDR (0.69) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2465073 | 0.83 | KDR (0.87) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371822-A1 | Heterobicyclic carboxamides as inhibitors for kinases | Novartis AG (CH) | 2011-10-05 | — | — | EP | claimed |