Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10261553 | 0.93 | TDP1 (0.47) | CYP3A4CKS1BSKP1SKP2TDP1 | |
| SCHEMBL2840695 | 0.93 | TDP1 (0.47) | CYP3A4CKS1BSKP1SKP2TDP1 | |
| SCHEMBL3974693 | 0.93 | TDP1 (0.47) | CYP3A4CKS1BSKP1SKP2TDP1 | |
| SCHEMBL2476921 | 0.92 | CYP3A4 (0.42) | CYP3A4CKS1BSKP1SKP2TDP1 | |
| Bromide SCHEMBL3972235 | 0.85 | CYP3A4 (0.41) | CYP3A4CKS1BSKP1SKP2TDP1 | |
| SCHEMBL12747338 | 0.84 | SMN1; SMN2 (0.51) | CYP3A4CKS1BSKP1SKP2TDP1 | |
| SCHEMBL12836400 | 0.83 | RECQL (0.44) | TDP1MAPTSMN1; SMN2LIN28AMEN1 | |
| SCHEMBL10282622 | 0.81 | CKS1B (0.46) | CKS1BSKP1SKP2TDP1MAPT | |
| SCHEMBL2469931 | 0.80 | SMN1; SMN2 (0.42) | TDP1MAPTSMN1; SMN2LIN28AKMT2A | |
| SCHEMBL22883030 | 0.80 | CA12 (0.53) | CYP3A4TDP1NPSR1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373622-A2 | CA-IX SPECIFIC RADIOPHARMACEUTICALS FOR THE TREATMENT AND IMAGING OF CANCER | Molecular Insight Pharmaceuticals, Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010065906-A2 | CA-IX SPECIFIC RADIOPHARMACEUTICALS FOR THE TREATMENT AND IMAGING OF CANCER | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |