Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24735131 | 1.00 | IRAK4 (0.51) | IRAK4LRRK2CRBNDDB1MAOA | |
| SCHEMBL29841629 | 1.00 | IRAK4 (0.51) | IRAK4LRRK2CRBNDDB1MAOA | |
| SCHEMBL24734957 | 1.00 | IRAK4 (0.51) | IRAK4LRRK2CRBNDDB1MAOA | |
| SCHEMBL24735203 | 0.97 | IRAK4 (0.52) | IRAK4LRRK2CRBNDDB1MAOA | |
| SCHEMBL29841322 | 0.96 | IRAK4 (0.51) | IRAK4LRRK2CRBNDDB1EGFR | |
| SCHEMBL24735571 | 0.96 | IRAK4 (0.51) | IRAK4LRRK2CRBNDDB1EGFR | |
| SCHEMBL20046733 | 0.91 | CRBN (0.44) | IRAK4LRRK2CRBNDDB1EGFR | |
| SCHEMBL24735128 | 0.90 | LRRK2 (0.51) | IRAK4LRRK2CRBNDDB1MAOA | |
| SCHEMBL29841559 | 0.90 | LRRK2 (0.51) | IRAK4LRRK2CRBNDDB1MAOA | |
| SCHEMBL24735576 | 0.90 | LRRK2 (0.51) | IRAK4LRRK2CRBNDDB1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530222-B2 | Substituted pyrrolopyrimidine and pyrazolopyrimidine as Bruton's tyrosine kinase (BTK) degraders | ACCUTAR BIOTECHNOLOGY INC. (US) | 2022-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530222-B2 | Substituted pyrrolopyrimidine and pyrazolopyrimidine as Bruton's tyrosine kinase (BTK) degraders | BTK, LYN, SYK | IRAK4 75/4885LRRK2 272/4885CRBN 692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.