Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | HPGD | P15428 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | SMPD3 | Q9NY59 | 10/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | PPARG | P37231 | 3/20 | 0.58 |
| ▸ | NCOA2 | Q15596 | 3/20 | 0.58 |
| ▸ | NCOA1 | Q15788 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30111647 | 0.92 | MAPT (0.79) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL24740658 | 0.89 | MAPT (0.63) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL24740569 | 0.85 | MAPT (0.58) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL24740653 | 0.85 | MAPT (0.58) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL21315904 | 0.85 | SMPD3 (0.85) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL24740657 | 0.85 | MAPT (0.65) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL24740766 | 0.83 | MAPT (0.55) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL24740570 | 0.83 | MAPT (0.55) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL24740764 | 0.83 | MAPT (0.54) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL24740763 | 0.83 | MAPT (0.54) | MAPTKDM4EALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261120-A1 | nSMASE2 INHIBITOR PRODRUGS WITH ENHANCED ORAL AND BRAIN EXPOSURES | THE JOHNS HOPKINS UNIVERSITY (US) | 2022-12-15 | — | — | WO | disclosed |