Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29919287 | 1.00 | USP30 (0.42) | USP30NR1H2JAK1JAK2ALDH1A1 | |
| SCHEMBL30367596 | 0.96 | USP30 (0.41) | USP30NR1H2JAK1JAK2ALDH1A1 | |
| SCHEMBL29919449 | 0.86 | NR1H2 (0.46) | USP30NR1H2JAK1JAK2ALDH1A1 | |
| SCHEMBL24575390 | 0.86 | NR1H2 (0.46) | USP30NR1H2JAK1JAK2ALDH1A1 | |
| SCHEMBL30367419 | 0.85 | NR1H2 (0.43) | USP30NR1H2JAK1JAK2ALDH1A1 | |
| SCHEMBL25260004 | 0.85 | USP30 (0.46) | USP30JAK1JAK2ALDH1A1MAPT | |
| SCHEMBL25296607 | 0.85 | USP30 (0.46) | USP30JAK1JAK2ALDH1A1MAPT | |
| SCHEMBL30488481 | 0.85 | USP30 (0.46) | USP30JAK1JAK2ALDH1A1MAPT | |
| SCHEMBL23956997 | 0.84 | NR1H2 (0.41) | USP30NR1H2JAK1JAK2POLB | |
| SCHEMBL30455542 | 0.84 | NR1H2 (0.41) | USP30NR1H2JAK1JAK2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212819-A1 | INDAZOLE DERIVATIVES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2022-10-06 | — | — | WO | disclosed |