Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24742489 | 0.87 | AURKA (0.39) | AURKAAURKBFGFR2FGFR3RIPK1 | |
| SCHEMBL24743112 | 0.80 | RET (0.40) | AURKAAURKBRETPLK4 | |
| SCHEMBL24741835 | 0.78 | AURKA (0.45) | AURKAIGF1R | |
| SCHEMBL24742406 | 0.74 | AURKA (0.43) | AURKAAURKBRETIGF1R | |
| SCHEMBL24742405 | 0.74 | RET (0.39) | AURKAAURKBRETPLK4 | |
| SCHEMBL24741818 | 0.72 | AURKA (0.44) | AURKAAURKBRETIGF1REGFR | |
| SCHEMBL24742500 | 0.72 | IGF1R (0.37) | AURKAAURKBRETIGF1REGFR | |
| SCHEMBL24743108 | 0.71 | HDAC3 (0.45) | AURKARET | |
| SCHEMBL24743066 | 0.70 | HDAC3 (0.44) | AURKARETIGF1R | |
| SCHEMBL24743111 | 0.69 | RET (0.47) | AURKARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022206888-A1 | CDK2 INHIBITORS AND USE THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2022-10-06 | — | — | WO | disclosed |