Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.73 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.73 |
| ▸ | PIK3C2G | O75747 | 14/20 | 0.73 |
| ▸ | AURKA | O14965 | 11/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.73 |
| ▸ | BRD4 | O60885 | 5/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.73 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.73 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.57 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.57 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24742704 | 0.90 | PIK3CD (0.73) | PIK3CDPIK3CGPIK3C2GAURKAAURKB | |
| SCHEMBL24742671 | 0.88 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3C2GAURKAAURKB | |
| SCHEMBL19457389 | 0.84 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3C2GAURKAAURKB | |
| SCHEMBL24742651 | 0.82 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3C2GAURKAAURKB | |
| SCHEMBL24742645 | 0.81 | PIK3CD (0.73) | PIK3CDPIK3CGPIK3C2GAURKAAURKB | |
| SCHEMBL24743571 | 0.81 | PIK3CD (0.73) | PIK3CDPIK3CGPIK3C2GAURKAAURKB | |
| SCHEMBL19457390 | 0.80 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3C2GAURKAAURKB | |
| SCHEMBL24742701 | 0.79 | PIK3CD (0.76) | PIK3CDPIK3CGPIK3C2GAURKAAURKB | |
| SCHEMBL24742652 | 0.78 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3C2GAURKAAURKB | |
| SCHEMBL24742639 | 0.77 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3C2GAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440084-B1 | PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING PI3K-MEDIATED DISORDERS | DANA FARBER CANCER INST INC (US) | 2022-12-21 | — | — | EP | disclosed |