Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | STK3 | Q13188 | 1/20 | 0.37 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246138 | 0.91 | PIK3CD (0.53) | PIK3CAPIK3CDPIK3CBCDK1CDK2 | |
| SCHEMBL248279 | 0.83 | PIK3CD (0.63) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL27866839 | 0.82 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBCDK1CDK2 | |
| SCHEMBL243776 | 0.80 | PIK3CA (0.52) | PIK3CAPIK3CD | |
| SCHEMBL247135 | 0.80 | PIK3CA (0.50) | PIK3CAPIK3CDLRRK2PIK3R2 | |
| SCHEMBL248664 | 0.79 | PIK3CA (0.41) | PIK3CACDK1CDK2SMG1CLK2 | |
| SCHEMBL27866925 | 0.79 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CB | |
| SCHEMBL248824 | 0.79 | PIK3CD (0.45) | PIK3CAPIK3CD | |
| SCHEMBL246948 | 0.78 | PIK3CD (0.49) | PIK3CAPIK3CDSMG1LRRK2PIK3R2 | |
| SCHEMBL246551 | 0.77 | HTT (0.39) | PIK3CACDK1CDK2SMG1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588471-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |