Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.75 |
| ▸ | BCL2 | P10415 | 4/20 | 0.72 |
| ▸ | ALB | P02768 | 1/20 | 0.72 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.63 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.62 |
| ▸ | CAMK2B | Q13554 | 4/20 | 0.62 |
| ▸ | CAMK2G | Q13555 | 4/20 | 0.62 |
| ▸ | MARK3 | P27448 | 3/20 | 0.62 |
| ▸ | NEK4 | P51957 | 3/20 | 0.62 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.62 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.62 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.62 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.62 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.62 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.62 |
| ▸ | AXL | P30530 | 2/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.62 |
| ▸ | EEF2K | O00418 | 1/20 | 0.62 |
| ▸ | BCL6 | P41182 | 1/20 | 0.62 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30000856 | 1.00 | MCL1 (0.75) | MCL1BCL2ALBBCL2L1PRKCD | |
| SCHEMBL4161471 | 0.89 | MCL1 (0.92) | MCL1BCL2ALBBCL2L1PRKCD | |
| SCHEMBL4164705 | 0.88 | MCL1 (0.77) | MCL1BCL2ALBBCL2L1PRKCD | |
| SCHEMBL4165286 | 0.87 | MCL1 (0.60) | MCL1BCL2ALBBCL2L1PRKCD | |
| SCHEMBL4166750 | 0.87 | MCL1 (0.88) | MCL1BCL2ALBBCL2L1PRKCD | |
| SCHEMBL4165474 | 0.86 | MCL1 (1.00) | MCL1BCL2ALBBCL2L1PRKCD | |
| SCHEMBL24745357 | 0.86 | MCL1 (0.58) | MCL1BCL2ALBBCL2L1PRKCD | |
| SCHEMBL30000839 | 0.86 | MCL1 (0.58) | MCL1BCL2ALBBCL2L1PRKCD | |
| SCHEMBL15622814 | 0.85 | MCL1 (0.77) | MCL1BCL2ALBBCL2L1 | |
| SCHEMBL4162155 | 0.85 | MCL1 (1.00) | MCL1BCL2ALBBCL2L1PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117957218-A | Targeted protein degradation using bifunctional compounds that bind to ubiquitin ligases and target MCL-1 proteins | 凯普托尔治疗学股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2022255888-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |