Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 15/20 | 0.43 |
| ▸ | BCL2 | P10415 | 3/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.39 |
| ▸ | NEK4 | P51957 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.39 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30000670 | 1.00 | MCL1 (0.43) | MCL1BCL2BCL2L1CDC25BHTR6 | |
| SCHEMBL30079953 | 0.88 | MCL1 (0.39) | MCL1BCL2BCL2L1 | |
| SCHEMBL28524865 | 0.88 | MCL1 (0.39) | MCL1BCL2BCL2L1 | |
| SCHEMBL30000950 | 0.88 | MCL1 (0.55) | MCL1BCL2BCL2L1IRAK1NEK4 | |
| SCHEMBL22436876 | 0.88 | MCL1 (0.55) | MCL1BCL2BCL2L1IRAK1NEK4 | |
| SCHEMBL22436674 | 0.85 | MCL1 (0.46) | MCL1BCL2BCL2L1IRAK1NEK4 | |
| SCHEMBL29470900 | 0.85 | MCL1 (0.46) | MCL1BCL2BCL2L1IRAK1NEK4 | |
| SCHEMBL30000206 | 0.83 | MCL1 (0.54) | MCL1BCL2BCL2L1NEK4PRKCD | |
| SCHEMBL24745215 | 0.83 | MCL1 (0.54) | MCL1BCL2BCL2L1NEK4PRKCD | |
| SCHEMBL24774225 | 0.80 | MCL1 (0.42) | MCL1BCL2BCL2L1IRAK1NEK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117957218-A | Targeted protein degradation using bifunctional compounds that bind to ubiquitin ligases and target MCL-1 proteins | 凯普托尔治疗学股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2022255888-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |