Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 18/20 | 0.46 |
| ▸ | BCL2 | P10415 | 2/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.40 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.40 |
| ▸ | NEK4 | P51957 | 2/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.40 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.40 |
| ▸ | EEF2K | O00418 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | BCL6 | P41182 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30000122 | 1.00 | MCL1 (0.46) | MCL1BCL2BCL2L1ALBPRKCD | |
| SCHEMBL30938996 | 0.92 | MCL1 (0.45) | MCL1BCL2BCL2L1ALBPRKCD | |
| SCHEMBL22436687 | 0.90 | MCL1 (0.47) | MCL1BCL2BCL2L1ALBPRKCD | |
| SCHEMBL29999937 | 0.90 | MCL1 (0.47) | MCL1BCL2BCL2L1ALBPRKCD | |
| SCHEMBL24745269 | 0.87 | MCL1 (0.58) | MCL1BCL2BCL2L1ALBPRKCD | |
| SCHEMBL30000896 | 0.83 | MCL1 (0.56) | MCL1BCL2BCL2L1PRKCDCAMK2B | |
| SCHEMBL24745163 | 0.83 | MCL1 (0.56) | MCL1BCL2BCL2L1PRKCDCAMK2B | |
| SCHEMBL22436730 | 0.82 | MCL1 (0.55) | MCL1BCL2BCL2L1ALBPRKCD | |
| SCHEMBL30000817 | 0.82 | MCL1 (0.55) | MCL1BCL2BCL2L1ALBPRKCD | |
| SCHEMBL22436674 | 0.81 | MCL1 (0.46) | MCL1BCL2BCL2L1ALBPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117957218-A | Targeted protein degradation using bifunctional compounds that bind to ubiquitin ligases and target MCL-1 proteins | 凯普托尔治疗学股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2022255888-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |