Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.33 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1334913 | 0.86 | NTRK1 (0.55) | NTRK1NTRK3NTRK2JAK2PDPK1 | |
| SCHEMBL1335503 | 0.83 | NR4A1 (0.42) | EPAS1CYP19A1 | |
| SCHEMBL2443498 | 0.77 | JAK2 (0.49) | NTRK1NTRK3NTRK2LRRK2JAK2 | |
| SCHEMBL1336580 | 0.76 | BTK (0.49) | NTRK1NTRK3NTRK2LRRK2JAK2 | |
| SCHEMBL5073657 | 0.73 | NR4A1 (0.54) | CYP19A1 | |
| SCHEMBL1333336 | 0.73 | CYP19A1 (0.43) | CYP19A1 | |
| SCHEMBL11481973 | 0.72 | NR4A1 (0.52) | CYP19A1 | |
| SCHEMBL1336206 | 0.70 | JAK2 (0.58) | JAK2PDPK1BTK | |
| SCHEMBL1336620 | 0.70 | JAK2 (0.58) | JAK2PDPK1BTK | |
| SCHEMBL1336197 | 0.69 | NTRK1 (0.60) | NTRK1NTRK3NTRK2JAK2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373626-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010069966-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-06-24 | — | — | WO | disclosed |