Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 11/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | MLYCD | O95822 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24746291 | 0.97 | HPGD (0.58) | HPGDTSHRKMT2AMEN1PLA2G7 | |
| SCHEMBL14345351 | 0.87 | KMT2A (0.77) | HPGDTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL12183401 | 0.87 | HPGD (0.67) | HPGDTSHRKMT2AMEN1PLA2G7 | |
| SCHEMBL13616256 | 0.86 | HPGD (0.67) | HPGDKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19088580 | 0.85 | HPGD (0.68) | HPGDTSHRKMT2AMEN1PLA2G7 | |
| SCHEMBL8234573 | 0.84 | HPGD (0.76) | HPGDTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL12569383 | 0.84 | HPGD (0.73) | HPGDTSHRKMT2APLA2G7ALDH1A1 | |
| SCHEMBL2655426 | 0.84 | KMT2A (0.73) | HPGDTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL19088583 | 0.83 | HPGD (0.62) | HPGDTSHRKMT2AMEN1PLA2G7 | |
| SCHEMBL29944147 | 0.83 | MEN1 (0.71) | HPGDTSHRKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |