Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.30 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.30 |
| ▸ | ITK | Q08881 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681952 | 0.84 | ADORA2A (0.53) | ADORA2AADORA2BCYP1A2TRPA1CHEK1 | |
| SCHEMBL8415606 | 0.81 | ADORA2A (0.50) | ADORA2AADORA2BCYP1A2TRPA1CHEK1 | |
| SCHEMBL13122059 | 0.79 | ADORA2A (0.52) | ADORA2AADORA2BCYP1A2TRPA1CHEK1 | |
| SCHEMBL8273052 | 0.78 | ADORA2A (0.47) | ADORA2AADORA2BCYP1A2CHEK1PDPK1 | |
| SCHEMBL562141 | 0.78 | ADORA2A (0.47) | ADORA2AADORA2BCYP1A2CHEK1PDPK1 | |
| SCHEMBL13122191 | 0.78 | ADORA2A (0.47) | ADORA2AADORA2BCYP1A2TRPA1MAPK1 | |
| SCHEMBL16867222 | 0.75 | ADORA2A (0.67) | ADORA2AADORA2BCYP1A2CHEK1PDPK1 | |
| SCHEMBL8221256 | 0.75 | ADORA2A (0.45) | ADORA2AADORA2BCYP1A2CHEK1DYRK1A | |
| SCHEMBL11970930 | 0.74 | ADORA2A (0.47) | ADORA2AADORA2BCYP1A2CHEK1PDPK1 | |
| SCHEMBL5678104 | 0.74 | ADORA2A (0.47) | ADORA2AADORA2BCYP1A2TRPA1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |