Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPR3 | P17342 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | ANPEP | P15144 | 2/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | LAP3 | P28838 | 1/20 | 0.32 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.32 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3336615 | 0.87 | CYP19A1 (0.34) | CYP19A1EPHX1SMN1; SMN2NPR3NLRP3 | |
| Hydrochloric Acid SCHEMBL3342710 | 0.86 | CYP19A1 (0.33) | CYP19A1EPHX1SMN1; SMN2NPR3NLRP3 | |
| SCHEMBL28201376 | 0.83 | CACNA1B (0.47) | CACNA1B | |
| SCHEMBL28201377 | 0.83 | CACNA1B (0.47) | CACNA1B | |
| SCHEMBL7780238 | 0.81 | CYP19A1 (0.39) | CYP19A1EPHX1SMN1; SMN2NLRP3NPC1 | |
| SCHEMBL7780240 | 0.81 | CYP19A1 (0.39) | CYP19A1EPHX1SMN1; SMN2NLRP3NPC1 | |
| SCHEMBL28774335 | 0.81 | — | — | |
| SCHEMBL2059164 | 0.81 | HDAC6 (0.36) | NLRP3RAB9AGAAALDH1A1HSD17B10 | |
| SCHEMBL12765185 | 0.81 | HDAC6 (0.36) | NLRP3RAB9AGAAALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL9876601 | 0.79 | HDAC6 (0.35) | NLRP3ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9511120-B2 | Use of the angiotensin-(1-9) peptide or derivatives thereof, use of vectors overexpressing the ACE2 enzyme that produces angiotensin-(1-9) for preparing medicaments useful for preventing, reverting, inhibiting and/or reducing hypertension and/or inducing vasodilation | PONTIFICA UNIVERSIDAD CATÓLICA DE CHILE (CL) | 2016-12-06 | — | — | US | disclosed |
| US-9132164-B2 | Pharmaceutical compositions comprising angiotensin-(1-9), derivatives thereof, or a vector expressing ACE2, useful for treating cardiovascular, pulmonary, cerebral, and/or renal remodeling | PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) | 2015-09-15 | — | — | US | disclosed |
| US-20150190472-A1 | USE OF THE ANGIOTENSIN-(1-9) PEPTIDE OR DERIVATIVES THEREOF, USE OF VECTORS OVEREXPRESSING THE ACE2 ENZYME THAT PRODUCES ANGIOTENSIN-(1-9) FOR PREPARING MEDICAMENTS USEFUL FOR PREVENTING, REVERTING, INHIBITING AND/OR REDUCING HYPERTENSION AND/OR INDUCING VASODILATION | PONTIFICA UNIVERSIDAD CATOLICA DE CHILE (CL) | 2015-07-09 | — | — | US | disclosed |
| EP-2377544-B1 | PHARMACEUTICAL COMPOSITION CONTAINING ANGIOTENSIN-(1-9) FOR CARDIOVASCULAR, PULMONARY AND/OR CEREBRAL TREATMENT | PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (CL) | 2014-10-22 | — | — | EP | disclosed |
| US-20120172301-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING ANGIOTENSIN-(1-9), DERIVATIVES THEREOF, OR A VECTOR EXPRESSING ACE2, USEFUL FOR TREATING CARDIOVASCULAR, PULMONARY, CEREBRAL, AND/OR RENAL REMODELING | PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) | 2012-07-05 | — | — | US | disclosed |
| EP-2377544-A2 | PHARMACEUTICAL COMPOSITION CONTAINING ANGIOTENSIN-(1-9) FOR CARDIOVASCULAR, PULMONARY AND/OR CEREBRAL TREATMENT | Pontificia Universidad Católica De Chile (CL) | 2011-10-19 | — | — | EP | disclosed |