Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL9958361 | 0.87 | GAA (0.34) | GAAALDH1A1LMNAHSD17B10 | |
| SCHEMBL8420585 | 0.87 | GAA (0.34) | GAAALDH1A1LMNAHSD17B10 | |
| SCHEMBL28492861 | 0.80 | MEN1 (0.38) | ALDH1A1HSD17B10MEN1KMT2ATSHR | |
| SCHEMBL28183567 | 0.78 | FFAR3 (0.35) | ALDH1A1MEN1CYP1A2THRBKMT2A | |
| SCHEMBL6313690 | 0.78 | GAA (0.38) | GAAALDH1A1LMNAHSD17B10 | |
| SCHEMBL6319563 | 0.78 | GAA (0.38) | GAAALDH1A1LMNAHSD17B10 | |
| SCHEMBL4610366 | 0.78 | GAA (0.38) | GAAALDH1A1LMNAHSD17B10 | |
| SCHEMBL284431 | 0.78 | CYP2C19 (0.42) | GAAALDH1A1TSHRTDP1 | |
| Acetic Acid SCHEMBL15573268 | 0.76 | CYP2C19 (0.41) | GAAALDH1A1TSHRFFAR3TDP1 | |
| Acetone SCHEMBL9653544 | 0.76 | CYP2C19 (0.41) | GAAALDH1A1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735332-B1 | AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LAB (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20080113982-A1 | AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS | ZHAO CHEN | 2008-05-15 | — | — | US | disclosed |
| US-7345034-B2 | Azacyclosteroid histamine-3 receptor ligands | ABBOTT LABORATORIES (US) | 2008-03-18 | — | — | US | disclosed |
| EP-1735332-A1 | AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2006-12-27 | — | — | EP | disclosed |
| US-20050245495-A1 | Azacyclosteroid histamine-3 receptor ligands | ABBOTT LABORATORIES | 2005-11-03 | — | — | US | disclosed |
| WO-2005100377-A1 | AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2005-10-27 | — | — | WO | disclosed |
| US-20050227953-A1 | Azacyclosteroid histamine-3 receptor ligands | ABBVIE INC. | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227953-A1 | Azacyclosteroid histamine-3 receptor ligands | HRH4, HRH3, HRH2 | GAA 3742/4885ALDH1A1 2714/4885LMNA 4497/4885 |
| US-20050245495-A1 | Azacyclosteroid histamine-3 receptor ligands | HRH4, HRH3, HRH2 | GAA 3742/4885ALDH1A1 2714/4885LMNA 4497/4885 |
| US-20080113982-A1 | AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS | HRH4, HRH3, HRH2 | GAA 3742/4885ALDH1A1 2714/4885LMNA 4497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.